The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. ex. Some numerals are expressed as "XNUMX".
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The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. Copyrights notice
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A eletrofisiologia, que é o estudo das propriedades elétricas dos tecidos e células biológicas, tornou-se indispensável na pesquisa clínica moderna, no diagnóstico, no monitoramento de doenças e na terapêutica. Neste artigo apresentamos uma breve história desta disciplina e como o projeto de circuitos integrados moldou a eletrofisiologia nas últimas décadas. Discutiremos como o design do amplificador biopotencial evoluiu da arquitetura clássica de três amplificadores operacionais para circuitos mais avançados de alto desempenho, permitindo o monitoramento vestível de longo prazo do sistema nervoso autônomo e central. Também discutiremos como esses circuitos integrados evoluíram para medir circuitos neurais in vivo. Este artigo é direcionado a leitores que são novos no domínio da gravação de biopotencial e desejam obter uma breve visão histórica e se atualizar sobre os principais conceitos de design de circuito para gravação de biopotencial vestível e in vivo.
Nick VAN HELLEPUTTE
imec
Carolina MORA-LOPEZ
imec
Chris VAN HOOF
imec,KU Leuven
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Nick VAN HELLEPUTTE, Carolina MORA-LOPEZ, Chris VAN HOOF, "Design of CMOS Circuits for Electrophysiology" in IEICE TRANSACTIONS on Electronics,
vol. E106-C, no. 10, pp. 506-515, October 2023, doi: 10.1587/transele.2022CTI0003.
Abstract: Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.
URL: https://global.ieice.org/en_transactions/electronics/10.1587/transele.2022CTI0003/_p
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@ARTICLE{e106-c_10_506,
author={Nick VAN HELLEPUTTE, Carolina MORA-LOPEZ, Chris VAN HOOF, },
journal={IEICE TRANSACTIONS on Electronics},
title={Design of CMOS Circuits for Electrophysiology},
year={2023},
volume={E106-C},
number={10},
pages={506-515},
abstract={Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.},
keywords={},
doi={10.1587/transele.2022CTI0003},
ISSN={1745-1353},
month={October},}
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TY - JOUR
TI - Design of CMOS Circuits for Electrophysiology
T2 - IEICE TRANSACTIONS on Electronics
SP - 506
EP - 515
AU - Nick VAN HELLEPUTTE
AU - Carolina MORA-LOPEZ
AU - Chris VAN HOOF
PY - 2023
DO - 10.1587/transele.2022CTI0003
JO - IEICE TRANSACTIONS on Electronics
SN - 1745-1353
VL - E106-C
IS - 10
JA - IEICE TRANSACTIONS on Electronics
Y1 - October 2023
AB - Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.
ER -